As we settle into 2025, research shows that the demand for and interest in weight-loss injections has exploded. According to online doctor, ZAVA, internet searches for Mounjaro (one of the most talked-about treatments) have increased by 3,881% since January 2024 – from 11,000 to 428,000.
A recent survey also revealed 24% of people would use weight-loss jabs if provided for free by the NHS – and a further 7% would be happy to buy them privately. One jab, Wegovy, is already available to some people on the NHS, and Mounjaro, will be available soon.
Alongside the near 30% of Brits prioritising health-related New Year’s resolutions, social media platform TikTok is thought to be a driving force behind this surge of interest – with thousands of videos dedicated to weight-loss treatments.
But what does the current research say?
How do weight-loss injections work?
In the UK, there are currently two weight-loss drugs available – semaglutide (marketed under the name Wegovy) and tirzepatide (sold as Mounjaro). Semaglutide is also used in Ozempic – a treatment for type 2 diabetes.
Both Wegovy and Mounjaro are taken as weekly injections, self-administered into the thigh, stomach, or upper arm. They work by mimicking a hormone called glucagon-like peptide-1 (GLP-1), which suppresses appetite. This is why experts refer to them as GLP-1 treatments.
Mounjaro also affects glucose-dependent insulinotropic polypeptide (GIP) – another hormone involved in metabolism and energy regulation.
But what does the research say?
Here’s what experts at ZOPA have to say about some common GLP-1 treatment myths…
1. GLP-1 treatments are ‘magic’ – False
While GLP-1 treatments can help to reduce appetite and increase fullness, they’re not a magic solution. For lasting results, treatment must be paired with regular exercise and a healthy, balanced diet.
2. GLP-1 treatments can help to regulate blood pressure – True
Research shows that GLP-1 treatments can help to control blood pressure – particularly in people with hypertension (high blood pressure). However, further studies are needed to confirm their efficacy for diabetes-related hypertension.
3. GLP-1 treatments can help anyone lose weight – False
GLP-1 treatments are only suitable for people with obesity, a BMI of 27, or other weight-related health conditions.
4. GLP-1 treatments are safe – Undetermined
Research has found that GLP-1 treatments can cause temporary side effects, such as nausea and bloating. While clinical studies suggest they’re safe for long-term use, it’s important to speak to a healthcare professional first to discuss suitability.
5. GLP-1 treatments may help to reduce inflammation – True
There’s growing evidence that GLP-1 treatments may help to reduce inflammation in several areas of the body, including the liver and brain – potentially offering benefits for conditions like Parkinson’s and Alzheimer’s disease.
6. GLP-1 treatments are addictive – False
There’s currently no evidence that GLP-1 treatments are addictive. Some animal studies even suggest they may reduce addictive behaviours.
7. GLP-1 treatments may affect mental health – Unknown
Initial studies suggest that GLP-1 treatments may benefit mental health. However, further research is needed.
Crystal Wyllie, a doctor at ZAVA, says: “Under proper medical supervision, weight loss injections can be a safe and effective tool for achieving lasting results. This growing awareness is an encouraging step toward reducing stigma and empowering more people to seek the right support for their health.”
Francesca Williams is a lifestyle writer at Rest Less. She joined Rest Less in early 2021 after achieving a first-class degree in History at the University of Sheffield and qualifying as an NCTJ Gold Standard Journalist. Francesca writes across a range of lifestyle topics, specialising in health, history, and art and culture. In her spare time, Francesca likes to keep herself busy and enjoys going on walks, playing netball, going to the gym, getting involved with her local church, and socialising with friends and family.
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