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We rely on a range of vitamins and minerals to stay healthy and energised. Among other things, many play a role in processes like breaking down food for energy and transporting oxygen around the body – so when our levels are low, we may feel tired or fatigued.
However, the good news is that upping your intake of certain vitamins and minerals can make all the difference to how energised you feel.
With that said, here are 11 vitamins and minerals that can help with tiredness and fatigue.
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If you’re looking for peace of mind and faster access to healthcare, HMCA’s member-only private medical plans have guaranteed acceptance and no age limit. For more information, you can visit their website below.
Note: It’s important to speak to your GP before adding any new supplements to your diet. Your GP will also be able to check your levels of certain vitamins and minerals via a blood test and give further advice if levels are low.
1. Vitamin B12
Vitamin B12 – also known as cobalamin – is one of eight essential B vitamins.
B vitamins are key to good health because they work together to help the body produce energy. According to research, each B vitamin, except folate (vitamin B9), is involved in energy production. And vitamin B12 is one of the most important.
As well as supporting nervous system function and forming DNA, B12 is needed to create red blood cells, which are responsible for carrying oxygen around the body. As a result, if you don’t have enough B12 in your system, it can impact oxygen delivery. This is why this vitamin is often linked with preventing anaemia – a condition that causes weakness and fatigue due to a lack of healthy red blood cells.
In this study, vitamin B12 deficiency was found to cause fatigue, shortness of breath, and reduced exercise tolerance. The symptoms improved with B12 supplementation.
We can’t produce vitamin B12 on our own, so we have to get it from our diet. Vitamin B12 deficiency is more common among older adults – affecting around one in 20 people aged 65-74 and one in 10 people aged 75 or over. This is because, as we age, the digestive system doesn’t produce as much acid, which impacts the body’s ability to absorb vitamin B12.
To learn more, check out our article: A beginner’s guide to vitamin B12 – benefits, deficiency, and diet tips.
2. CoQ10
Coq10 is a type of coenzyme that the body produces naturally. Coenzymes are small molecules that support enzymes in carrying out chemical processes in the body. All body cells contain CoQ10, but levels are highest in the heart, liver, and kidneys.
CoQ10 is responsible for stimulating cells to produce the body’s main energy-carrying molecule, Adenosine Triphosphate (ATP). More specifically, research shows that CoQ10 is effective at speeding up ATP production, allowing the body to use food more efficiently for energy.
This substance also has antioxidant properties, which help protect cells from becoming damaged. For this reason, when CoQ10 levels are low, cells can’t produce the energy they need to grow and remain healthy, which studies show can contribute to tiredness and fatigue.
CoQ10 levels naturally decrease with age, and research shows that certain cancers, heart failure, type 2 diabetes, or taking statins can also cause lower levels. Plus, because studies suggest that many foods don’t offer large enough amounts of CoQ10 to significantly increase levels in the body, some people may benefit from taking supplements.
For more information, have a read of our article: What is CoQ10, and why is it important for our health?
3. Vitamin D
Vitamin D is a fat-soluble vitamin. It occurs naturally in a small number of foods, like oily fish and mushrooms, and our bodies also produce it when ultraviolet rays from the sun hit our skin.
Vitamin D is known mainly for its role in maintaining healthy bones and teeth, but it can also help beat tiredness and fatigue.
In this study of patients struggling with chronic fatigue, 77.2% were found to have low levels of vitamin D. After increasing their vitamin D intake, fatigue symptoms significantly improved. Another study also found that vitamin D supplements significantly reduced fatigue in healthy people.
Research has also drawn a link between low vitamin D levels and an increased risk of depression, of which fatigue is a common symptom.
For further reading, check out our article: What is vitamin D and why do we need it to stay healthy?
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4. Vitamin B1
Vitamin B1, or thiamine, is involved in several important health functions, including energy production, growth, development, and cell function.
It’s used by nearly all cells in the body and is needed to convert food into energy, so upping your intake can be an effective way to boost energy levels.
This study looked at people in inflammatory bowel disease (IBD) remission who were suffering from chronic fatigue unexplained by deficiencies in iron, folic acid, vitamin D, B12, or any other health conditions. After taking high-dose vitamin B1 supplements for four weeks, patients reported significantly less fatigue, despite their bowel symptoms remaining largely unchanged.
Another study found that vitamin B1 supplements helped improve symptoms of fibromyalgia – a condition characterised by fatigue, chronic pain, and sleep disorders.
Check out our article, An introduction to vitamin B1, to learn more.
5. Iron
Iron is an essential mineral that our bodies need to function properly. We rely on iron to make haemoglobin – a protein found in red blood cells, which is responsible for transporting oxygen around the body.
As a result, when our iron levels are low, we’re unable to produce enough healthy red blood cells, and our bodies can’t get enough oxygen-rich blood. This can leave us feeling tired and lacking in energy. Over time, this may result in iron deficiency anaemia – which is known to cause weakness and fatigue.
In this study, which looked at unexplained fatigue in menstruating women, participants who took iron supplements over 12 weeks experienced a 47.7% decrease in fatigue. Those in the placebo group experienced only a 28.8% decrease.
Our article, Iron – what it is, why it’s important, and how to make sure you’re getting enough, has more information.
Note: People with hemochromatosis need to be particularly cautious about taking iron supplements. While most people only absorb around 10% of the iron they consume, people with hemochromatosis may absorb up to 30%. This is why, before taking any new supplements, it’s important to speak to your GP about whether they’re right for you.
6. Vitamin B3
Vitamin B3, or niacin, is needed to convert food into energy and for over 200 reactions in the body.
B3 also plays a role in the production of the hormone serotonin, which regulates mood and sleep patterns. Low levels of vitamin B3 (and therefore serotonin) can increase the risk of depression, which is often associated with fatigue. In fact, mental health conditions like depression and anxiety are some of the most common symptoms associated with vitamin B3 deficiency.
In line with this, the results of this study found that vitamin B3 may help reduce fatigue and drowsiness in older adults.
To learn more, you might like our article: An essential guide to niacin (vitamin B3).
7. Zinc
Zinc is an essential trace mineral involved in the chemical processes that break down food and turn it into energy – so, when we don’t have enough, it’s normal to feel tired and fatigued.
Research has also found that zinc deficiency can affect taste, smell, and appetite. Naturally, our energy levels will suffer when we don’t fuel our bodies with enough food.
Our article, 7 health benefits of zinc and how to make sure you’re getting enough, has more information.
8. Vitamin B6
Vitamin B6, also known as pyridoxine, is a water-soluble nutrient stored in the body in small amounts.
It’s involved in over 100 chemical reactions throughout the body, including the production of haemoglobin. So, low B6 levels can impact oxygen supply throughout the body, and this is likely why anaemia is a common symptom of deficiency.
Vitamin B6 is also essential for healthy metabolism because it’s involved in the breakdown of glycogen stores, which are located in the muscles and liver, and used for energy.
For more information, check out our article: What is vitamin B6 and how can I make sure I’m getting enough?
9. Vitamin C
Vitamin C is essential for healthy body function – including repairing damaged tissues, protecting cells, and maintaining healthy blood vessels. It’s also key to keeping energy levels boosted.
We need vitamin C to convert food into energy and to absorb other vitamins and minerals effectively. For example, some studies suggest that vitamin C can increase iron absorption by around 67%. As a result, this study found that vitamin C supplements reduced fatigue.
Our article, Everything you need to know about vitamin C, has more information about this essential vitamin.
10. Magnesium
Magnesium is needed for the production and regulation of ATP (the body’s main energy-carrying molecule), as well as for the conversion of food into energy. So, not getting enough can disrupt these processes and increase tiredness and fatigue.
Magnesium can also improve sleep quality by helping activate neurotransmitters that promote relaxation.
In this study, older adults who took magnesium supplements had better sleep quality compared to a placebo group. They also displayed higher levels of melatonin, a hormone involved in sleep regulation. This 2025 research also found that magnesium supplementation improved poor sleep quality in adults suffering from insomnia.
You can learn more in our guide: Magnesium – what it is and why it’s important.
Worried about accessing the NHS care you need?
83% of Rest Less members are worried about accessing the healthcare they need on the NHS#, making fast access to treatment more important than ever.
HMCA private medical cover offers affordable, flexible plans, with 90% of members saving money when they switch. Enjoy peace of mind. Join today and get £150 off your subscription.
#Data from over 1,000 Rest Less members surveyed in 2025
^Data from HMCA members who joined between 01/01/25 and 30/06/25
11. Vitamin B2
Like other B vitamins, B2, or riboflavin, helps convert food into energy.
However, it plays a particularly important role in producing energy for the heart and muscles – meaning a deficiency can significantly impact our energy levels and movement.
Our bodies also rely on vitamin B2 to absorb iron, which we need for red blood cell production and oxygen transportation. As a result, low B2 levels can cause tiredness, weakness, and fatigue – and increase the risk of anaemia.
Our article, Why vitamin B2 is important and how to get enough, has more information.
Final thoughts…
We rely on several vitamins and minerals to feel energised and function at our best. So, if you’ve been struggling with tiredness or fatigue recently, making sure you’re getting enough essential vitamins and minerals can make all the difference.
Note: It’s important to speak to your GP before adding any new supplements to your diet. Your GP will also be able to check your levels of certain vitamins and minerals and give further advice if levels are low.
For further reading, head over to our diet and nutrition section, where you’ll find everything from energy-boosting foods and drink ideas to healthy recipe inspiration.
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If you’re looking for peace of mind and faster access to healthcare, HMCA’s member-only private medical plans have guaranteed acceptance and no age limit. For more information, you can visit their website below.
Which vitamins and minerals help you with tiredness and fatigue? Has anything in this article surprised you? We’d be interested to hear from you in the comments below.
* Links with an * by them are affiliate links which help Rest Less stay free to use as they can result in a payment or benefit to us. You can read more on how we make money here.
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